Past Projects

From October 2003 to October 2004 I worked as a project student in Liisa Holm's group at Institute of Biotechnology in Helsinki, Finland. The project was to find the sequence alignment of the distant proteins, using closely spaced intermediate sequences. These transitive pairwise alignments help to find very sparse sequence motifs accurately for the sequences which are very distantly related in the evolution space. Maxflow algorithm, was tested and benchmarked against the urease superfamily, and found to yield better reliability and almost double coverage compared to available sequence-alignment softwares. more information can be found here: Accurate Detection of Very Sparse Sequence Motifs A Heger, M Lappe, L Holm - Journal of Computational Biology, 2004

Past Projects